To investigate which type of ET1 receptor, ETAR or ETBR, contributes to the regulation of anxiety, we also measured ETAR and ETBR mRNA levels in the same samples used in Figure 1c, and we found that the effects of interactions were not significant in Figure S1b (F1,8 = 0.115, P = 0.743), or in Figure S1c (F1,8 = 2.851, P = 0.030). This evidence concerns the gene EDNRA and Anxiety.