The anxiolytic effect of the BLA ET1-ETBR signaling pathway, through activating the TGF-β, may counter the anxiogenic effect of the infralimbic ET1-ETAR signaling pathway, through activating the NF-κB complex, in normal mice, and the imbalance of these pathways would lead to anxiety disorders. This evidence concerns the gene NFKB1 and anxiety disorder.