These results highlight the complex interplay in BAs and lipid homeostasis, and suggest that, 1) CA-induced dyslipidaemia is partially dependent on TRPC5 activity, while 2) CA-induced repression of CYP7A1, known to be dependent on FXR and other factors/mediators35, is independent of TRPC5. This evidence concerns the gene TRPC5 and inherited lipid metabolism disorder.