Among these genes (Appendix Table S2), many are involved in tumour suppression [e.g. RB1 (Dyson, 2016)], apoptosis [e.g. BCL2L1 (Liu et al, 2015)], the cell cycle [e.g. CCND1 (Mende et al, 2015), CCND2 (Khanjyan et al, 2013)] or protein kinases [e.g. KIT (Wichmann et al, 2015), GSK3‐β (Orme et al, 2016)]. The gene discussed is RB1; the disease is neoplasm.