Interestingly, AML1‐ETO bound to the promoter of miR‐383 and activated its expression, while miR‐383 in turn suppressed expression of THAP10. Therefore, these findings indicate that AML1‐ETO inhibits expression of the tumour suppressor THAP10 directly via epigenetic suppression of the THAP10 promoter and indirectly through transcriptional activation of miR‐383 in t(8;21) AML (Fig 7I). The gene discussed is RUNX1T1; the disease is acute myeloid leukemia.