Together, these findings indicate that AML‐ETO recruits p300 to the AML1‐binding sites in the pre‐miR‐383 regulatory region and therefore transcriptionally activates miR‐383 expression, which in turn suppresses THAP10 expression, suggesting an alternative indirect mechanism for AML‐ETO to negatively regulate THAP10 expression in t(8;21) AML. Here, EP300 is linked to acute myeloid leukemia.