By combined with 408 differentially methylated genes (Fig 1B), a systematic survey of the publicly available databases (Gardini et al, 2008; Zhang et al, 2015) identified nine transcriptional factor genes targeted by AML1‐ETO that were differentially hypermethylated in t(8;21) AML (Fig 1D). Here, RUNX1 is linked to acute myeloid leukemia.