CRTC1 and neoplasm: Frequent mutations were identified in several relevant genes, including CRTC1 (CREB-regulated transcription coactivator 1), CCND1/BCL1 (G1/S-specific cyclin-D1), PTCH1 (protein patched homolog 1), and JAK1 (tyrosine-protein kinase JAK1), although many were subclonal (present in only a small fraction of cells), consistent with significant heterogeneity within the tumor.