Furthermore, the majority of the patients (89%; 155 of 175) were diagnosed with stage II or III MSI+ CRC, and the prognostic association of JAK1 frameshift indels was independent of cancer stage in these patients (multivariable HR = 0.1 [0.02–0.8], P = 0.03; Additional file 2: Figure S6b). Here, JAK1 is linked to cancer.