The activation of MMP1-PAR1 induces the secretion of angiogenic factors of interleukin 8 (IL-8) and growth-regulated oncogene-alpha from ovarian carcinoma cells, which act on endothelial CXCR1/2 receptors in a paracrine manner, leading to endothelial cell proliferation, tube formation and migration. The gene discussed is CXCR1; the disease is ovarian carcinoma.