The association of the points obtained in the score with the occurrence ofanticoagulation adverse events (major bleeding, stroke, systemic embolism and/ordeath) has been described in other studies8,10-12,16,17 after the originalstudy,9 always relating thequality of anticoagulation, assessed via TTR, with the occurrence of those outcomes.Only the study by Poli et al.13has not observed that relationship. This evidence concerns the gene TTR and stroke disorder.