Among the most prominent examples are the Aβ peptides in Alzheimer (AD), α-synuclein in Parkinson (PD), prion protein in prion deposits typical of Creutzfeldt–Jakob disease (CJD), and superoxide dismutase-1 (SOD-1) in amyotrophic lateral sclerosis (ALS). Here, SNCA is linked to amyotrophic lateral sclerosis.