KEAP1 and Hepatic fibrosis: For example, miR-200a can regulate the Keap1/Nrf2 pathway in HSCs and hepatic fibrosis through the association of Nrf2 with Keap1, which results in cytoplasmic Nrf2 degradation and interference with induction of genes that encode antioxidant enzymes, such as NQO1 [73].