Lee et al. [41] demonstrated that apigenin (4′,5,7-trihydroxyflavone), a natural flavonoid, inhibits HGF-induced (Hepatocyte growth factor) which controls invasive growth of MDA-MB-231 human breast cancer cells, including their motility, scattering, migration, and invasion; through blocking the PI3K/Akt pathway. Here, AKT1 is linked to breast carcinoma.