Furthermore, in a mouse bone marrow transplantation model, FLT3-TKD not only manifested a malignancy with longer latency compared to FLT3-ITD, but it was also found to cause an oligoclonal lymphoid disease, in contrast to FLT3-ITD, which led to the development of a myeloproliferative disorder [121]. This evidence concerns the gene FLT3 and myeloproliferative disorder.