First, durations of some included studies were short, study period was insufficient, only 1 study evaluated the long-term efficiency (including the clinical changes in laboratory values of interest) and safety of SGLT2 inhibitors (including the event of malignant neoplasm); thus, longer duration of observation is needed to understand the long-term benefits and risks of SGLT2 inhibitors. This evidence concerns the gene SLC5A2 and cancer.