Our data show that RUNX1-ETO-binding sites are enriched for occupied ETS/RUNX/E-box motifs, reflecting the structure of the RUNX1-ETO complex, with the ETS factors ERG and FLI1 in the complex being required for leukemia maintenance and leukemogenesis (Martens et al., 2012, Sun et al., 2013). The gene discussed is RUNX1; the disease is leukemia.