ERG and leukemia: Our data show that RUNX1-ETO-binding sites are enriched for occupied ETS/RUNX/E-box motifs, reflecting the structure of the RUNX1-ETO complex, with the ETS factors ERG and FLI1 in the complex being required for leukemia maintenance and leukemogenesis (Martens et al., 2012, Sun et al., 2013).