These comparisons uncovered profound differences in gene expression profiles and DHS patterns between t(8;21) and t(3;21) AML, in particular with HOXA-associated genes such as HOXA9 and its partner gene, MEIS1, which are highly expressed in t(3;21) malignancies, but not in t(8;21) AML (Figures 1B, S1A, and S1B). Here, HOXA9 is linked to acute myeloid leukemia.