Because we have previously shown that microdeletion of 22q11DS genes increases Drd2 levels in the auditory thalamus (Chun et al., 2014) and that the auditory thalamus is important for the delivery of the CS to the amygdala—and thus for emotional memory—we hypothesized that fear memory is impaired in 22q11DS mice and that this deficit could be due to Dgcr8–Drd2-dependent impairment of synaptic transmission at thalamo-LA projections. Here, DRD2 is linked to 22q11.2 deletion syndrome.