The abnormal increase in Drd2 in the auditory thalamus of 22q11DS mice enhances dopamine-Drd2 signaling in thalamic projections and disrupts glutamatergic synaptic transmission at thalamocortical (TC) (Chun et al., 2014) and thalamo-LA projections. Here, DRD2 is linked to 22q11.2 deletion syndrome.