Six studies reported ALCAM expression in CRC patients with clinical tumor stages and our analysis showed that ALCAM overexpression was associated with advanced tumor stage [pooled OR (T3,T4 vs. T1,T2) = 2.66, 95%CI = 2.01–3.51, P < 0.0001; Figure 4). The gene discussed is ALCAM; the disease is colorectal carcinoma.