Based on our results showing IRF8 overexpression in the DLBCL tumor microenvironment and previous findings showing that IRF8 inhibits Th17 differentiation in CD4+T cells in mice [26], we investigated whether IRF8 affected the generation of Th17 cells in the tumor microenvironment in vitro. The gene discussed is IRF8; the disease is diffuse large B-cell lymphoma.