Conversely, the expression of PI3K, AKT, mTOR, p-PI3K, p-AKT and p-mTOR decreased, indicating that tunicamycin treatment induced ERS in SKOV3 cells and inhibited the PI3K/AKT/mTOR pathway (Figure 2B). This evidence concerns the gene AKT1 and amelogenesis imperfecta type 1G.