In this study, we used the ovarian cancer cell line SKOV3 and the drug-resistant cell lines SKOV3/CDDP to explore the relation of ERS and the PI3K/AKT/mTOR signaling pathway with autophagy, apoptosis and chemoresistance of SKOV3 and SKOV3/CDDP. The gene discussed is AKT1; the disease is ovarian cancer.