Our co-IP and PLA results provide clear evidence for a GD2/c-Met association, and are consistent with observations by P. Delannoy's group that GD2 is involved in c-Met activation and subsequent activation of MEK/Erk and PI3K/Akt signaling pathways, leading to enhanced breast cancer cell migration and proliferation [15, 16]. This evidence concerns the gene MAP2K7 and breast carcinoma.