BCL2 and ischemia: Up-regulation of anti-apoptotic members of the Bcl-2 family, including Bcl-2 and Bcl-xL, has been reported to be mediated by p38 in carbon monoxide-protected ischemia/reperfusion injury of the lung [41], and in HaCaT keratinocytes exposed to ultraviolet A (UVA) [42].