CASP3 and cervical cancer: In summary, results of these experiments demonstrate that α-mangostin enhances ROS amounts to activate the ASK/p38 signaling pathway and damage the integrity of mitochondria, including loss of MMP, increase of Bax and cytochrome C release, and decrease of Bcl-2, leading to activation of caspase-9/caspase-3 cascade, and induction of apoptosis in cervical cancer cells (Figure 8).