In addition, α-mangostin repressed epithelial-mesenchymal transition (EMT) by down-regulating the PI3K/Akt pathway [20] and inhibited activation of pancreatic stellate cells (PSCs), an EMT-like process, by suppressing production of hypoxia-driven ROS in pancreatic cancer [13]. This evidence concerns the gene AKT1 and familial pancreatic carcinoma.