Results of the present study have shown that α-mangostin induces generation of ROS to activate the ASK/p38 signaling pathway and rupture mitochondria, followed by loss of MMP, increase of Bax and cytochrome C release, decrease of Bcl-2, leading to triggering caspase-9/caspase-3 cascade and inducing apoptosis in cervical cancer cells. Here, CASP9 is linked to cervical carcinoma.