For example, POU5F1 (also known as OCT4), functioning in stem cell pluripotency and embryonic development, was hypomethylated in 98.13% of the 268 cancer samples, which is concordant with the findings that this gene is overexpressed in CRC [14] and may contribute to CRC development [15]. The gene discussed is POU5F1; the disease is colorectal carcinoma.