CDC42 and endometriosis: For rs2268177, there was no significant evidence of heterogeneity (PHEIDI=0.065) in effect sizes of dependent SNPs at this associated region and therefore it is very likely that rs2268177 contributes to both endometriosis risk and the expression level of CDC42. Significant heterogeneity (PHEIDI<0.05) may indicate the possibility of two causal variants at a locus: one affecting endometriosis risk and the other affecting expression level of the gene (Supplementary Data 15).