Using the TCGA data, we found a correlation in lung adenocarcinoma between CD8a (P=0.028 using a simple linear regression model) and CD103 gene expression (P=0.001 using a single-linear regression model) and mutational burden (Supplementary Fig. 7), suggesting that these intratumoural CD8+T cells may recognize neoepitopes. The gene discussed is ITGAE; the disease is lung adenocarcinoma.