To identify the cellular source of IL-1β secretion, we first examined the expression levels of NLRP3 inflammasome components in APCs (BMDCs and BMDMs) and EG7 tumour cells and found that NLRP3 and pro-IL-1β were not detected in EG7 cells, even after LPS stimulation (Supplementary Fig. 5l). Here, NLRP3 is linked to neoplasm.