There is an atypical CpG island near the promoter of LRRC25, and treatment of AML cell lines with demethylation drugs up-regulated expression of LRRC25 (Fig. S4A and S4B), suggesting that epigenetic regulation plays a role in controlling LRRC25 expression, directly or indirectly. The gene discussed is LRRC25; the disease is acute myeloid leukemia.