TXNRD1 and hepatocellular carcinoma: We found TXNRD1 mRNA level was significantly upregulated in HCC tissues compared to liver nontumor tissues (p < 0.0001), mRNA expression profiles of HCC and liver nontumor tissues came from GSE14520 (Figure 1(a)), we also used The Cancer Genome Atlas (TCGA) dataset to analyze TXNRD1 expression, and TXNRD1 mRNA level was also significantly upregulated in HCC tissues compared to normal live tissues (p < 0.0001) (Figure 1(b)).