We investigated the relationship between TXNRD1 level and clinicopathological characteristics of HCC patients and found that TXNRD1 level was significantly correlated with clinical stage (p = 3.5e − 5) and N classification (p = 4.4e − 4 using Chi-square test, p = 0.001 using Fisher's exact test). Here, TXNRD1 is linked to hepatocellular carcinoma.