It has also been proposed that stimulation of ADCC is an underlying mechanism for cetuximab’s clinically meaningful activity and the comparatively notable response rates with first- and second-line treatment in patients with R/M SCCHN, which set it apart from other mAb EGFR inhibitors (e.g., panitumumab) (33). Here, EGFR is linked to head and neck squamous cell carcinoma.