The first 60 patients (“Cohort B”) were selected for PD-L1–positive tumors and treated with 10 mg/kg pembrolizumab intravenously every 2 weeks, and the remaining 132 patients (“Cohort B2”) were unselected for tumor PD-L1 expression and treated with pembrolizumab at a fixed dose of 200 mg intravenously every 3 weeks (13, 45, 82). This evidence concerns the gene CD274 and neoplasm.