Finally, ongoing trials with durvalumab include the phase 2 HAWK study (monotherapy in second-line, PD-L1-positive R/M SCCHN following a single platinum-based treatment), and the phase 3 EAGLE study (monotherapy or combination with tremelimumab in second-line R/M SCCHN following a single platinum-based treatment) (14, 65, 66, 85, 86). This evidence concerns the gene CD274 and head and neck squamous cell carcinoma.