Furthermore, a study by Irving E. Vega showed that, in rat renal NRK cells, Exo70 could be observed on the edge of migrating cells [19]; in HeLa cells, Exo70 expression inhibition could reduce the rate of cell migration [9]; in prostate cancer cells, reduction of the expression of Exo70 inhibited tumor cell migration and invasion [30]; in breast cancer cells, over expression of Exo70 promoted cell migration and invasion, and RNAi knocking-down its expression level inhibited cell migration and invasion [7]. The gene discussed is EXOC7; the disease is prostate carcinoma.