In the pathogenesis of atherosclerosis, oxidized low-density lipoproteins (ox-LDL) cause injury, activation and dysfunction of the endothelium via lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which is overexpressed in both early and advanced atherosclerotic lesions [1]. The gene discussed is OLR1; the disease is atherosclerosis.