TCF4 and metastatic malignant neoplasm in the lymph nodes: Univariate analysis showed that, among the clinicopathological factors examined in this study, the extent of primary tumor (risk ratio, 4.184; p < 0.0001), lymph node metastasis (risk ratio, 4.149; p < 0.0001), lymphatic invasion (risk ratio, 6.622; p = 0.003), vein invasion (risk ratio, 2.816; p = 0.0003), and immunostaining for TCF4/TCF7L2 (risk ratio, 2.506; p = 0.0049) were statistically significant prognostic factors.