Recent studies identified several genes and molecules involved in the origin and/or progression of esophageal cancer, including TP53 [1], deleted in esophageal cancer 1 (DEC1) [2], deleted in colorectal cancer (DCC) [3], deleted in lung cancer 1 (DLC1) [4], cyclin D1 [5], adenomatous polyposis coli (APC) [6], and survivin [7]. The gene discussed is DELEC1; the disease is esophageal cancer.