In contrast to “conventional” CD25+FoxP3+CD4+ Treg (cTreg), which exhibited similar frequencies in HIV-TB coinfected patients, HIV+ individuals latently infected with TB (HIV-TBL), HIV+ persons, and HD (Figure 1A), uTreg frequencies were significantly higher in HIV-TB than HD (Figure 1B) similar to our previous results (7). This evidence concerns the gene CD4 and tuberculosis.