Models of murine depression and stress-resistance have been generated by using the GR-heterozygous mutant mice (GR+/−) that under-express GRs, or the YGR mice that over-express GRs (Ridder et al., 2005; Schulte-Herbrüggen et al., 2006). The gene discussed is BCL2A1; the disease is depressive symptom measurement.