CRP and neoplasm: To date, some blood proteins and enzymes, such as canine C-reactive protein (CRP) and thymidine kinase, have been studied as low-invasive biomarkers for canine tumours3; however, these protein-based markers were found to be difficult for fully meeting the clinical demand as tumour biomarkers because their activities are easily affected by a change in the storage temperature and numerous other clinical conditions including inflammation.