The conventional ACE/AngII/AT1R pathway was also reported to be involved in different experimental bone diseases including age-related osteoporosis in mice45, bone deteriorations following obstructive nephropathy46 or type 1 diabetes47, postmenopausal osteoporosis in OVX animals7, 10 and glucocorticoid-induced osteoporosis48. The gene discussed is ACE; the disease is postmenopausal osteoporosis.