In addition, low AGE diets compared to high AGE diets reduced TNFα, VCAM-1, 8-isoprostane, leptin, circulating AGE levels, receptor for AGE, and P66shc, and increased adiponectin levels and sirtuin-1 in PMNC in both individuals with and without T2DM. Here, SIRT1 is linked to type 2 diabetes mellitus.