The MERS-CoV genome is ~30 kb and encodes the 5′-replicase structuralprotein (spike-envelope-membrane-nucleocapsid)-poly (A)-3′.13, 14, 15 The highly glycosylated spike (S) proteinmediates viral infections and is a primary determinant of cell tropism and pathogenesis. The gene discussed is CHMP5; the disease is viral infectious disease.