More notably, the NTD and CTD of two α-CoVs, porcineepidemic diarrhea CoV and transmissible gastroenteritis, might both play vital roles inviral infection.47, 48 The NTD of MERS-CoV is also glycosylated, and theneutralizing mAb 5F9 may bind to the glycan or other residues of the NTD, stabilizing thepre-fusion conformation of the S protein and the S1–S2 interaction, thereby precluding theDPP4- and/or co-receptor-induced conformational changes required for membrane fusion. The gene discussed is PROS1; the disease is infection.