We previously showed that treating cultured myotubes with LLC cell-conditioned medium (LCM) recapitulates the muscle catabolism seen in LLC tumor-bearing mice through the activation of the p38 MAPK-C/EBPβ signaling pathway which upregulates E3 ubiquitin ligases atrogin18 and UBR225. The gene discussed is CEBPB; the disease is neoplasm.