HGF and breast carcinoma: Significant increase in serum HGF levels was found in patients compared with healthy subjects. Serum level of HGF is an independent prognostic indicator of breast cancer. Fibrocystic disease of the breast showed weak HGFR expression, while in normal tissue, HGFR was scanty; breast invasive ductal carcinoma showed homogenous strong reaction to HGFR. Preoperative high serum HGF levels and malignancy occur together. MET overexpression in tumors was a poor prognostic factor for OS [120].