High HGF is produced to promote liver regeneration post-hepatectomy, which was used for the treatment of liver metastasis of CRC. HGF produced after hepatectomy may stimulate the progression of CRC cells with MET in residual liver. Results from 94 CRC patients including 24 with liver metastasis showed that MET overexpression was closely associated with CRC liver metastases (87% of 24 patients), while in liver metastatic lesions, the MET expression level was reduced in comparison to primary lesions [115]. The gene discussed is HGF; the disease is metastasis.