CAFs secrete monocyte chemotactic protein 1 (MCP1/CCL2) and stromal-cell-derived factor 1 (SDF1), also known as CXCL12, which are involved in the recruitment of myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) [36]. Here, CXCL12 is linked to neoplasm.