This results in various actions: CCL17 and CCL22, in turn, are chemo-attractants that bring more Treg cells to the tumor sites; CD39 and CD73 enhance the suppressor functions of Treg cells [47,48]; IL-9 produced by Treg cells helps to maintain the survival of mast cells [49] which further contribute to the establishment of inflammatory and immuno-suppressive conditions at the tumor site by secretion of pro-inflammatory and immunosuppressive cytokines and chemokines. This evidence concerns the gene NT5E and neoplasm.