Moreover, at the tumor site, the IL-1 and IL-6 cytokines, the S100A8 and S100A9 pro-inflammatory proteins, the chemo-attractant molecules CCL2, SDF1 and CXCL5 are the main factors responsible for the recruitment and the induction of MDSCs [42,43]. The gene discussed is CXCL12; the disease is neoplasm.