In mammary tumor cells, HGF/c-MET was found to regulate the signal transducer and activator of transcription 3 (Stat3) and MAP kinase signaling pathways by pharmacologic inhibition and small interfering RNA silencing, revealing a cooperative interaction between the two pathways to regulate HGF-induced invasion, scattering, and motility of mammary tumor cells [70]. This evidence concerns the gene HGF and breast cancer.