Among other chemokines and cytokines secreted at tumor sites by immune cells, SDF1, a potent chemo-attractant for endothelial cells, the chemokines CCL2, CXCL8, CXCL1, CXCL13, and RANTES contribute to the neo-angiogenesis [36,39]. This evidence concerns the gene CXCL12 and neoplasm.