MET and chordoma: Recently, Duan and colleagues showed that miR-1 was downregulated in 93.7% of chordoma tissues and its expression was inversely correlated with c-Met expression, indicating that suppressed miR-1 expression in chordoma may in part be a driver for tumor growth, and that miR-1 has the potential to serve as a prognostic biomarker and therapeutic target for chordoma patients [46].