MET and colorectal cancer: Another study conducted by Reid et al. showed that miR-1 can have a tumor-suppressor function in colorectal cancer by directly downregulating c-Met oncogene both at the RNA and protein levels and that reexpression of miR-1 leads to c-Met-driven reduction of cell proliferation and motility, identifying miR-1 downmodulation as one of the events that could enhance colorectal cancer progression [48].