Analysis of biopsies from melanoma lesions treated by intratumoral T-VEC injection induced both local and systemic T lymphocyte responses, as well as decreased CD4+FoxP3+ regulatory T cells (Tregs) and CD8+FoxP3+ suppressor T cells (Ts), both of which are inversely correlated with patient survival [76]. The gene discussed is FOXP3; the disease is melanoma.