For instance, a strain of measles virus encoding the sodium iodide symporter (MV-NIS) was developed by Russell and colleagues at the Mayo Clinic (Rochester, MN, USA, 2004), engineered to express the human thyroidal sodium iodide symporter (NIS), in a way that in vivo viral infection could be noninvasively monitored by radioiodine single-photon emission computed tomography (SPECT)—computed tomography (CT) imaging [120]. The gene discussed is SLC5A5; the disease is viral infectious disease.