TGFB1 and neoplasm: An example of a whole tumor cell vaccine in ovarian cancer is gemogenovatucel-T (FANG vaccine); it consists of autologous tumor cells eletroporated with FANG vector, a plasmid encoding GM-CSF (granulocyte macrophage-colony stimulating factor; a potent stimulator of dendritic cell maturation) and a bi-shRNA targeting furin convertase, thereby downregulating endogenous immunosuppressive growth factors TGF-β1 and β2 [33].