CD8A and neoplasm: Different routes of antigen-coding mRNA delivery has been analyzed in a mouse model, showing that following intranodal injection, resident DCs in the nodes selectively took up the mRNA, inducing potent CD4+ and CD8+ T cell responses after repeated i.n. injections in tumor-bearing mice, which was not observed with subcutaneous, intradermal, or near nodal administrations [123].