In a pilot clinical study including seven stage III colon cancer patients receiving standard adjuvant oxaliplatin/capecitabine chemotherapy and vaccinated at the same time with keyhole limpet hemocyanin (KLH) and carcinoembryonic antigen (CEA)-peptide pulsed DCs, an enhanced non-specific T-cell reactivity upon oxaliplatin administration was observed, results that support further testing of the combined use of tumor vaccination with oxaliplatin-based chemotherapy [168]. This evidence concerns the gene CEACAM5 and malignant colon neoplasm.