MSLN and neoplasm: Finally, when using whole tumor cell extracts (either loading DCs or by direct vaccination), immunogenicity could be enhanced by adding specific molecules, such as a fusion protein of single-chain antibody variable fragment (scFv) mesothelin (MSLN), to Mycobacterium tuberculosis (MTB) heat shock protein 70 (HSP70), which is a potent immune activator able to stimulate monocytes and DCs, enhancing DC maturation and aggregation, and improving cross-priming of T cells.