Provenge® is an autologous DC-based vaccine (developed by Dendreon), in which autologous peripheral blood mononuclear cells (PBMC) are matured with a cytokine and a tumor-derived differentiation agent, and then pulsed with a fusion protein composed of prostatic acid phosphatase (PAP; a tumor-associated differentiation antigen) linked to GM-CSF prior to reinfusion into patients [64]. Here, CSF2 is linked to neoplasm.