Angiogenin (Ang) belongs to the RNase superfamily and is a human analogue of bovine RNase A. Ang has several seemingly contradictory functions in physiologically healthy tissues and in tumors [34]: via nuclear ribonuclease activity it is involved in signaling pathways promoting cell proliferation, angiogenesis, migration and invasion—all hallmarks of tumor progression. Here, ANG is linked to neoplasm.