OV-mediated cell killing results in the release of tumor-associated antigens (TAAs), pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) from the lysed tumor cells, inducing markers of immunogenic cell death, such as membrane-associated calreticulin (ecto-CRT) and the release of high mobility group box 1 (HMGB1), ATP, and heat shock protein 70 and 90 (Hsp70 and Hsp90) [63]. This evidence concerns the gene HMGB1 and neoplasm.