In a similar study, a VSV vector encoding for mouse IFNβ and the sodium-iodide symporter (rVSV-mIFNβ-NIS) was applied in combination with anti-PD-L1, which resulted in the enhanced therapeutic outcome of the oncolytic virus therapy by application of immune checkpoint blockade in mice bearing acute myeloid leukemia (AML) [159]. The gene discussed is CD274; the disease is acute myeloid leukemia.