For example, the combination of oncolytic New Castle disease virus with an anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA)-4 blocking antibody resulted in over 60% cures in the murine B16F10 melanoma model and 100% protection against tumour rechallenge while either treatment alone was unable to cure any of the animals in this experimental setting [62]. Here, CTLA4 is linked to melanoma.