IGHE and Eczematoid dermatitis: The study will examine the influence of the study intervention on the rate of treatment failure, rate of alternative systemic therapy, quality of life, eczema severity as assessed by the Eczema Area and Severity Index (EASI), effect on co-existing allergic disease, number of eczema exacerbations, infective episodes of eczema, change in reactivity to food and aeroallergens and change in allergen-specific IgE.