NOS2 and multiple sclerosis: Furthermore, a previous study found that the intermediate product in the synthesis of austrasulfone, dihydroaustrasulfone alcohol, decreases the expression of proinflammatory cytokines such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX2), thus alleviating neuropathic pain and multiple sclerosis in rats regulating lipid metabolism in macrophages, and inhibiting restenosis [35,36,37,38].