DDIT3 and breast neoplasm: Moreover, Hahm and colleagues reported that WA-induced apoptosis was mediated through reactive oxygen species and Nagalingam et al. found that WA inhibited breast tumor formation in vivo through the activation of the extracellular signal-regulated kinases/ribosomal S6 kinase (ERK/RSK) axis, death receptor 5 (DR5) upregulation, and elevated nuclear accumulation of ETS domain-containing protein (Elk1) and C/EBP homologous protein (CHOP) in breast cancer [19,36].