Intriguing examples include N-terminal truncated isoforms of ELF2 and TCF4 (members of the Ets family of transcription factors and DNA binding transcriptional regulators of the Wnt pathway, respectively)40, 41, and ectopic expression of the well-established oncogene FOXR2 (refs 42, 43) in three independent ovine tumours (Fig. 3b,c). The gene discussed is TCF4; the disease is neoplasm.