Notably, reduced expression of LOXL1 in elastin-rich, load-bearing tissues such as the lamina cribrosa has been suggested as a major susceptibility factor for PEX glaucoma because of the accompanying elastotic and biomechanical tissue alterations24, 33, and may be also a predisposing factor for cardiovascular complications including aortic aneurysms in PEX patients6, 7, 8. The gene discussed is LOXL1; the disease is glaucoma.