SOS1 and brain disorder: The pathogenetic relevance of miR-132 regulated processes during development is further supported by the presence of brain disease related genes among the developmentally regulated miR-132 targets altered in the miR-132/212 mutant including MeCP2 (ref. 57), Pten (ref. 58), Ras-regulating genes Sos1 and Rasa1 (ref. 59), Mmp16 (ref. 60), Runx1t1 (ref. 61), Sox11 (ref. 62), Sox5 (ref. 63) and Gpd2 (ref. 64).