The pathogenetic relevance of miR-132 regulated processes during development is further supported by the presence of brain disease related genes among the developmentally regulated miR-132 targets altered in the miR-132/212 mutant including MeCP2 (ref. 57), Pten (ref. 58), Ras-regulating genes Sos1 and Rasa1 (ref. 59), Mmp16 (ref. 60), Runx1t1 (ref. 61), Sox11 (ref. 62), Sox5 (ref. 63) and Gpd2 (ref. 64). This evidence concerns the gene RASA1 and brain disorder.